Acceptability of an “on-demand” pre-exposure HIV prophylaxis trial among men who have sex with men living in France
- 15 November 2011
- journal article
- Published by Taylor & Francis Ltd in AIDS Care
- Vol. 24 (4), 468-477
- https://doi.org/10.1080/09540121.2011.626394
Abstract
Although predictors of willingness to take daily, self-administered pre-exposure HIV prophylaxis (PrEP) for men who have sex with men (MSM) have been studied in the context of several PrEP trials internationally, little is known about MSM interested in participating in a trial on the use of PrEP on an “on -demand” basis, i.e., taking a first dose of combined tenofovir/emtricitabine a few hours before possible HIV sexual exposure and a second dose a few hours afterwards. A double-blind placebo randomized PrEP trial will soon begin in France to evaluate the effectiveness of PrEP in terms of reducing HIV infection rates, among MSM self-administering “on-demand” PrEP. To assess potential participants’ characteristics associated with willingness to participate in the trial and identify barriers and facilitators to implementation, MSM completed a self-administered questionnaire, distributed via gay venues and community websites. Among the 443 respondents who reported being HIV-negative, 40% reported being interested in participating. Factors independently associated with interest included: reporting lower educational level, more than 20 male sexual partners in the previous year, reporting unprotected anal sex with casual partners and preferring PrEP follow-up visits in a devoted area within a hospital. There is great interest in participating in a future “on-demand” PrEP trial among HIV-negative MSM and particularly in those at potentially high risk of HIV exposure. Providing confidentiality and tailored counseling during PrEP follow-up are important issues.Keywords
This publication has 32 references indexed in Scilit:
- Acceptability of pre-exposure prophylaxis as an HIV prevention strategy: barriers and facilitators to pre-exposure prophylaxis uptake among at-risk Peruvian populationsInternational Journal of STD & AIDS, 2011
- Preexposure Chemoprophylaxis for HIV Prevention in Men Who Have Sex with MenThe New England Journal of Medicine, 2010
- Effectiveness and Safety of Tenofovir Gel, an Antiretroviral Microbicide, for the Prevention of HIV Infection in WomenScience, 2010
- Oral pre-exposure prophylaxis for HIV preventionTrends in Pharmacological Sciences, 2010
- Sexual risk behaviour of men who have sex with men: emerging patterns and new challengesCurrent Opinion in Infectious Diseases, 2010
- Systemic Administration of Antiretrovirals Prior to Exposure Prevents Rectal and Intravenous HIV-1 Transmission in Humanized BLT MicePLOS ONE, 2010
- Internet y riesgo sexual en hombres que tienen sexo con hombresGaceta Sanitaria, 2009
- Prevention of Rectal SHIV Transmission in Macaques by Daily or Intermittent Prophylaxis with Emtricitabine and TenofovirPLoS Medicine, 2008
- Men who have sex with men in Great Britain: comparison of a self-selected internet sample with a national probability sampleSexually Transmitted Infections, 2006
- Risk compensation: the Achilles' heel of innovations in HIV prevention?BMJ, 2006