Semisynthesis of Isetexane Diterpenoid Analogues and Their Cytotoxic Activity
Open Access
- 1 January 2006
- journal article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 54 (11), 1602-1604
- https://doi.org/10.1248/cpb.54.1602
Abstract
Isetexane diterpene analogues were semisynthesized from demethylsalvicanol isolated from Perovskia abrotanoides (Labiatae). The structure and cytotoxic activity relationships (SAR) of the natural parent diterpene, demethylsalvicanol, and its semisynthetic analogues were studied by using P388 murine leukemia cells.Keywords
This publication has 10 references indexed in Scilit:
- Cytotoxicity of abietane diterpenoids from Perovskia abrotanoides and of their semisynthetic analoguesBioorganic & Medicinal Chemistry, 2006
- Biomimetic synthesis of grandione from demethylsalvicanol via hetero-Diels–Alder type dimerization and structure revision of grandioneTetrahedron Letters, 2005
- Diterpenes from Salvia broussonetii Transformed Roots and Their Insecticidal ActivityJournal of Agricultural and Food Chemistry, 2005
- Leishmanicidal, Antiplasmodial, and Cytotoxic Activity of Novel Diterpenoid 1,2-Quinones from Perovskia abrotanoides: New Source of TanshinonesJournal of Natural Products, 2001
- An Eremophylane-Type Sesquiterpene and Diterpenes from Roots ofSalvia MelliferaNatural Product Letters, 1999
- New Solvent-Free Organic Synthesis Using Focused MicrowavesSynthesis, 1998
- Diterpenes from Salvia melliferaPhytochemistry, 1991
- Abietane diterpenoids from Lepechinia meyeni and Lepechinia hastataPhytochemistry, 1991
- A Novel Rearranged Abietane Diterpene From Coleus barbatusBulletin des Sociétés Chimiques Belges, 1989
- Isolation, structure determination, and absolute configuration of barbatusol, a new bioactive diterpene with a rearranged abietane skeleton from the labiate coleus barbatusTetrahedron, 1983