The Prehistory of Antibiotic Resistance
Open Access
- 1 June 2016
- journal article
- review article
- Published by Cold Spring Harbor Laboratory in Cold Spring Harbor Perspectives in Medicine
- Vol. 6 (6), a025197
- https://doi.org/10.1101/cshperspect.a025197
Abstract
Antibiotic resistance is a global problem that is reaching crisis levels. The global collection of resistance genes in clinical and environmental samples is the antibiotic “resistome,” and is subject to the selective pressure of human activity. The origin of many modern resistance genes in pathogens is likely environmental bacteria, including antibiotic producing organisms that have existed for millennia. Recent work has uncovered resistance in ancient permafrost, isolated caves, and in human specimens preserved for hundreds of years. Together with bioinformatic analyses on modern-day sequences, these studies predict an ancient origin of resistance that long precedes the use of antibiotics in the clinic. Understanding the history of antibiotic resistance is important in predicting its future evolution.Keywords
This publication has 54 references indexed in Scilit:
- Pediatric Fecal Microbiota Harbor Diverse and Novel Antibiotic Resistance GenesPLOS ONE, 2013
- antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producersNucleic Acids Research, 2013
- Next-generation phylogenomicsBiology Direct, 2013
- Novel resistance functions uncovered using functional metagenomic investigations of resistance reservoirsFrontiers in Microbiology, 2013
- Genome-scale coestimation of species and gene treesGenome Research, 2012
- The Shared Antibiotic Resistome of Soil Bacteria and Human PathogensScience, 2012
- Antibiotic Resistance Is Prevalent in an Isolated Cave MicrobiomePLOS ONE, 2012
- Evolution of the mutation rateTrends in Genetics, 2010
- A Major Clade of Prokaryotes with Ancient Adaptations to Life on LandMolecular Biology and Evolution, 2008
- Sampling the Antibiotic ResistomeScience, 2006