Sampling the Antibiotic Resistome
Top Cited Papers
- 20 January 2006
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 311 (5759), 374-377
- https://doi.org/10.1126/science.1120800
Abstract
Microbial resistance to antibiotics currently spans all known classes of natural and synthetic compounds. It has not only hindered our treatment of infections but also dramatically reshaped drug discovery, yet its origins have not been systematically studied. Soil-dwelling bacteria produce and encounter a myriad of antibiotics, evolving corresponding sensing and evading strategies. They are a reservoir of resistance determinants that can be mobilized into the microbial community. Study of this reservoir could provide an early warning system for future clinically relevant antibiotic resistance mechanisms.Keywords
This publication has 24 references indexed in Scilit:
- Uncultured soil bacteria are a reservoir of new antibiotic resistance genesEnvironmental Microbiology, 2004
- Structural Transitions as Determinants of the Action of the Calcium-Dependent Antibiotic DaptomycinCell Chemical Biology, 2004
- Occurrence, Structure, and Mobility of Tn 1546 -Like Elements in Environmental Isolates of Vancomycin-Resistant EnterococciApplied and Environmental Microbiology, 2004
- Life without dihydrofolate reductase FolATrends in Microbiology, 2003
- Baseline Study To Determine In Vitro Activities of Daptomycin against Gram-Positive Pathogens Isolated in the United States in 2000-2001Antimicrobial Agents and Chemotherapy, 2003
- Vancomycin Assembly: Nature's WayAngewandte Chemie, 2003
- A signal transduction system in Streptomyces coelicolor that activates the expression of a putative cell wall glycan operon in response to vancomycin and other cell wall‐specific antibioticsMolecular Microbiology, 2002
- Antimicrobial Resistance among Clinical Isolates of Streptococcus pneumoniae in the United States during 1999–2000, Including a Comparison of Resistance Rates since 1994–1995Antimicrobial Agents and Chemotherapy, 2001
- Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial ResistanceMicrobiology and Molecular Biology Reviews, 2001
- Inactivation of Antibiotics and the Dissemination of Resistance GenesScience, 1994