Comparison of tumour-based (Petersen Index) and inflammation-based (Glasgow Prognostic Score) scoring systems in patients undergoing curative resection for colon cancer
Open Access
- 10 February 2009
- journal article
- clinical trial
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 100 (5), 701-706
- https://doi.org/10.1038/sj.bjc.6604926
Abstract
After resection, it is important to identify colon cancer patients, who are at a high risk of recurrence and who may benefit from adjuvant treatment. The Petersen Index (PI), a prognostic model based on pathological criteria is validated in Dukes’ B and C disease. Similarly, the modified Glasgow Prognostic Score (mGPS) based on biochemical criteria has also been validated. This study compares both the scores in patients undergoing curative resection of colon cancer. A total of 244 patients underwent elective resection between 1997 and 2005. The PI was constructed from pathological reports; the mGPS was measured pre-operatively. The median follow-up was 67 months (minimum 36 months) during which 109 patients died; 68 of them from cancer. On multivariate analysis of age, Dukes’ stage, PI and mGPS, age (hazard ratio, HR, 1.74, P=0.001), Dukes’ stage (HR, 3.63, PP=0.010) and mGPS (HR, 2.34, PP<0.05). The high-risk PI population is small, in particular for Dukes’ B disease (9%). The mGPS further stratifies those patients classified as low risk by the PI. Combining both the scoring systems could identify patients who have undergone curative surgery but are at high-risk of cancer-related death, therefore guiding management and trial stratification.Keywords
This publication has 16 references indexed in Scilit:
- The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancerColorectal Disease, 2008
- The relationship between tumour T-lymphocyte infiltration, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancerBritish Journal of Cancer, 2005
- C-Reactive Protein: An Activator of Innate Immunity and a Modulator of Adaptive ImmunityImmunologic Research, 2004
- Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small-cell lung cancerBritish Journal of Cancer, 2003
- Prognostic molecular markers for planning adjuvant chemotherapy trials in Dukes’ B colorectal cancer patients: how much evidence is enough?Annals Of Oncology, 2003
- Inflammation and cancerNature, 2002
- Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancerGut, 2002
- Preoperative Elevation of Serum C-Reactive Protein Is Related to Impaired Immunity in Patients With Colorectal CancerAmerican Journal of Clinical Oncology, 2000
- Stimulation of tumour growth by wound-derived growth factorsBritish Journal of Cancer, 1999
- The Spread of Rectal Cancer and its Effect on PrognosisBritish Journal of Cancer, 1958