γδ T cell subsets: A link between TCR and function?
- 31 August 2010
- journal article
- review article
- Published by Elsevier BV in Seminars in Immunology
- Vol. 22 (4), 193-198
- https://doi.org/10.1016/j.smim.2010.03.006
Abstract
The γδ T lmphocytes are often divided into subsets based upon expression of certain TCR components. This division was initially made because γδ T cells residing in particular epithelia were found to show tissue specific differences in their TCRs. Many examples now show that γδ T cell subsets also appear to be biased to carry out particular functions. This suggests that particular γδ TCR types direct the cells to acquire a certain type of functional programming during thymic development. Here, we describe functionally distinct, TCR-defined γδ T cell subsets, and evidence that their functions are predetermined in the thymus.Keywords
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