IL‐17‐producing γδ T cells
Open Access
- 12 March 2009
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 39 (3), 662-666
- https://doi.org/10.1002/eji.200839120
Abstract
IL-17 is produced not only by CD4+ αβ T cells, but also CD8+ αβ T cells, NKT cells, and γδ T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, γδ T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.Keywords
Funding Information
- NIH (R01AI44920, R01HL65410)
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