Harnessing nanotopography and integrin–matrix interactions to influence stem cell fate
Top Cited Papers
- 21 May 2014
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Materials
- Vol. 13 (6), 558-569
- https://doi.org/10.1038/nmat3980
Abstract
Stem cells respond to nanoscale surface features, with changes in cell growth and differentiation mediated by alterations in cell adhesion. The interaction of nanotopographical features with integrin receptors in the cells' focal adhesions alters how the cells adhere to materials surfaces, and defines cell fate through changes in both cell biochemistry and cell morphology. In this Review, we discuss how cell adhesions interact with nanotopography, and we provide insight as to how materials scientists can exploit these interactions to direct stem cell fate and to understand how the behaviour of stem cells in their niche can be controlled. We expect knowledge gained from the study of cell-nanotopography interactions to accelerate the development of next-generation stem cell culture materials and implant interfaces, and to fuel discovery of stem cell therapeutics to support regenerative therapies.Keywords
This publication has 115 references indexed in Scilit:
- A genomics approach in determining nanotopographical effects on MSC phenotypeBiomaterials, 2013
- Embryonic and Induced Pluripotent Stem Cells: Understanding, Creating, and Exploiting the Nano-Niche for Regenerative MedicineACS Nano, 2013
- Nanotopography Influences Adhesion, Spreading, and Self-Renewal of Human Embryonic Stem CellsACS Nano, 2012
- Nanolithographic Control of the Spatial Organization of Cellular Adhesion Receptors at the Single-Molecule LevelNano Letters, 2011
- Nanotopography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cellsBiomaterials, 2010
- Interaction between the inner nuclear membrane lamin B receptor and the heterochromatic methyl binding protein, MeCP2Experimental Cell Research, 2009
- Impact of Order and Disorder in RGD Nanopatterns on Cell AdhesionNano Letters, 2009
- A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human OrgansCell Stem Cell, 2008
- Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 DegradationMolecular Cell, 2008
- Controlling the double helixNature, 2003