Functional replacement of Drosophila Btk29A with human Btk in male genital development and survival
- 6 July 2005
- journal article
- Published by Wiley in FEBS Letters
- Vol. 579 (19), 4131-4137
- https://doi.org/10.1016/j.febslet.2005.06.042
Abstract
Drosophila type 2 Btk29A reveals the highest homology to Btk among mammalian Tec kinases. In Btk29A(ficP) mutant males, the apodeme holding the penis split into two pieces. Human Btk rescued this phenotype in 39% of Btk29A(ficP) males, while the Drosophila transgenes did so in 90-100% of mutants. The Btk29A(ficP) mutation reduced adult longevity to 11% that of wild-type. This effect was counteracted by Drosophila type 2, yielding 76% of the wild-type lifespan. Human Btk extended the lifespan of Btk29A(ficP) mutants only to 20% that of wild-type. Thus human Btk can partially replace Drosophila Btk29A+ in male genital development and survival.This publication has 36 references indexed in Scilit:
- src64andtec29are required for microfilament contraction duringDrosophilacellularizationDevelopment, 2004
- Phosphorylation of α-synuclein characteristic of synucleinopathy lesions is recapitulated in α-synuclein transgenic DrosophilaNeuroscience Letters, 2003
- Phosphorylation of Bruton’s tyrosine kinase by c-AblBiochemical and Biophysical Research Communications, 2002
- The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other speciesBioEssays, 2001
- A Drosophila model of Parkinson's diseaseNature, 2000
- Identification and Characterization of a Novel SH3-Domain Binding Protein, Sab, Which Preferentially Associates with Bruton's Tyrosine Kinase (Btk)Biochemical and Biophysical Research Communications, 1998
- X‐linked agammaglobulinemia (XLA): A genetic tyrosine kinase (Btk) diseaseBioEssays, 1996
- Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID MiceScience, 1993
- Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency GenesScience, 1993
- Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemiaCell, 1993