Phosphorylation of Bruton’s tyrosine kinase by c-Abl
- 6 December 2002
- journal article
- Published by Elsevier BV in Biochemical and Biophysical Research Communications
- Vol. 299 (3), 510-515
- https://doi.org/10.1016/s0006-291x(02)02643-8
Abstract
Bruton's tyrosine kinase (Btk) is necessary for B-lymphocyte development. Mutation in the gene coding for Btk causes X-linked agammaglobulinemia (XLA) in humans. Similar to Btk, c-Abl is a tyrosine kinase shuttling between the cytoplasm and the nucleus where it is involved in different functions depending on the localization. In this report we describe for the first time that c-Abl and Btk physically interact and that c-Abl can phosphorylate tyrosine 223 in the SH3 domain of Btk. Interestingly, the Btk sequence matched a v-Abl substrate [correction] identified from a randomized peptide library and was also highly related to a number of previously found c-Abl substrates.Keywords
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