The effects of calcitriol and nicotinamide on residual pancreatic β‐cell function in patients with recent‐onset Type 1 diabetes (IMDIAB XI)
- 26 July 2006
- journal article
- research article
- Published by Wiley in Diabetic Medicine
- Vol. 23 (8), 920-923
- https://doi.org/10.1111/j.1464-5491.2006.01921.x
Abstract
Background: A number of recent studies underline the importance of vitamin D in the pathogenesis of Type 1 diabetes (T1D). Aims: The aim of this study was to investigate whether supplementation with the active form of vitamin D (calcitriol) in subjects with recent-onset T1D protects residual pancreatic β-cell function and improves glycaemic control (HbA1c and insulin requirement). Methods: In this open-label randomized trial, 70 subjects with recent-onset T1D, mean age 13.6 years ± 7.6 SD were randomized to calcitriol (0.25 μg on alternate days) or nicotinamide (25 mg/kg daily) and followed up for 1 year. Intensive insulin therapy was implemented with three daily injections of regular insulin + NPH insulin at bedtime. Results: No significant differences were observed between calcitriol and nicotinamide groups in respect of baseline/stimulated C-peptide or HbA1c 1 year after diagnosis, but the insulin dose at 3 and 6 months was significantly reduced in the calcitriol group. Conclusions: At the dosage used, calcitriol has a modest effect on residual pancreatic β-cell function and only temporarily reduces the insulin dose. © 2006 The AuthorsKeywords
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