1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.
- 23 July 1996
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 93 (15), 7861-7864
- https://doi.org/10.1073/pnas.93.15.7861
Abstract
Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.This publication has 17 references indexed in Scilit:
- Prevention of murine experimental allergic encephalomyelitis: cooperative effects of cyclosporine and 1 α, 25-(OH)2D3Journal of Neuroimmunology, 1995
- Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.The Journal of Experimental Medicine, 1995
- Escape from “horror autotoxicus”: Pathogenesis and treatment of autoimmune diseaseCell, 1995
- The immunopathogenesis and regulation of T-cell-mediated demyelinating diseasesImmunology Today, 1994
- 1,25-Dihydroxyvitamin D3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitroImmunology Letters, 1993
- New Concepts of Vitamin D FunctionsaAnnals of the New York Academy of Sciences, 1992
- 1,25-dihydroxyvitamin D3 prevents the in vivo induction of murine experimental autoimmune encephalomyelitis.JCI Insight, 1991
- Regulation of lymphokine production and human T lymphocyte activation by 1,25-dihydroxyvitamin D3. Specific inhibition at the level of messenger RNA.JCI Insight, 1987
- 1 alpha,25-dihydroxyvitamin D3 suppresses proliferation and immunoglobulin production by normal human peripheral blood mononuclear cells.JCI Insight, 1984
- 1,25-Dihydroxyvitamin D 3 Receptors in Human LeukocytesScience, 1983