Mechanisms of Autocatalysis
Top Cited Papers
- 11 October 2013
- journal article
- review article
- Published by Wiley in Angewandte Chemie
- Vol. 52 (49), 12800-12826
- https://doi.org/10.1002/anie.201303822
Abstract
Self-replication is a fundamental concept. The idea of an entity that can repeatedly create more of itself has captured the imagination of many thinkers from von Neumann to Vonnegut. Beyond the sciences and science fiction, autocatalysis has found currency in economics and language theory, and has raised ethical fears memorably summed up by the “gray goo” trope. Autocatalysis is central to the propagation of life and intrinsic to many other biological processes. This includes the modern conception of evolution, which has radically altered humanity’s image of itself. Organisms can be thought of as imperfect self-replicators which produce closely-related species, allowing for selection and evolution. Hence, any consideration of self-replication raises one of the most profound questions of all: what is life? Minimal self-replicating systems have been studied with the aim of understanding the principles underlying living systems, allowing us to refine our concepts of biological fitness and chemical stability, self-organization and emergence, and ultimately to discover how chemistry may become biology.This publication has 103 references indexed in Scilit:
- Rates and equilibria of ester hydrolysis: Combination of slow and rapid reactionsChemical Engineering and Processing - Process Intensification, 2011
- Light‐Induced Peptide Replication Controls Logic Operations in Small NetworksChemistry – A European Journal, 2010
- Self‐Replicating Amphiphilic β‐Sheet PeptidesAngewandte Chemie, 2009
- Evolution and self-assembly of protocellsThe International Journal of Biochemistry & Cell Biology, 2009
- The Road to Non‐Enzymatic Molecular NetworksAngewandte Chemie, 2008
- Autocatalytic behaviour in esterification between anhydrides and alcoholsThermochimica Acta, 2006
- Spontaneous absolute asymmetric synthesis in the presence of achiral silica gel in conjunction with asymmetric autocatalysisChirality, 2006
- Systems Chemistry: Kinetic and Computational Analysis of a Nearly Exponential Organic ReplicatorAngewandte Chemie, 2005
- Sub-exponential growth and coexistence of non-enzymatically replicating templatesJournal of Theoretical Biology, 1989
- Autocatalysis in the formose reactionReaction Kinetics, Mechanisms and Catalysis, 1980