Dietary polyunsaturated fatty acids and breast cancer risk in Chinese women: A prospective cohort study
Open Access
- 28 September 2010
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 128 (6), 1434-1441
- https://doi.org/10.1002/ijc.25703
Abstract
Breast cancer is the most common cancer in women. Controversy exists regarding the role of dietary fat in breast cancer etiology. We investigated the association of dietary polyunsaturated fatty acids (PUFAs) and the ratio of n‐6 PUFAs to marine‐derived n‐3 PUFAs with breast cancer risk in the Shanghai Women's Health Study, a prospective cohort study including 72,571 cancer‐free participants at baseline. Dietary fatty acid intake was determined using food frequency questionnaires. We used Cox proportional hazards analysis to estimate the relative risks (RRs) and 95% confidence intervals (CIs) for the association of breast cancer risk with dietary fatty acids consumption. In 583,998 person‐years of follow‐up, we identified 712 breast cancer cases. We found no association of breast cancer risk to dietary intake of linoleic acid, arachidonic acid, α‐linolenic acid or marine‐derived n‐3 PUFA. We found a statistically significant interaction between n‐6 PUFA intake, marine‐derived n‐3 PUFA intake and breast cancer risk (p = 0.008). Women with lower intake (the lowest tertile) of marine‐derived n‐3 PUFA and higher intake (the highest tertile) of n‐6 PUFA had an increase risk for breast cancer (RR = 2.06; 95% CI = 1.27–3.34) compared to women with higher intake (the highest tertile) of marine‐derived n‐3 PUFAs and lower intake (the lowest tertile) of n‐6 PUFAs after adjusting for potential confounders. The relative amounts of n‐6 PUFA to marine‐derived n‐3 PUFAs may be more important for breast cancer risk than individual dietary amounts of these fatty acids.This publication has 45 references indexed in Scilit:
- Association of serum phospholipid fatty acids with breast cancer risk among postmenopausal cigarette smokersCancer Causes & Control, 2009
- Dietary intakes of ω‐6 and ω‐3 polyunsaturated fatty acids and the risk of breast cancerInternational Journal of Cancer, 2008
- Diet, Cancer, and the LipidomeCancer Epidemiology, Biomarkers & Prevention, 2006
- Role of Lipid Peroxidation in the Epidemiology and Prevention of Breast CancerCancer Epidemiology, Biomarkers & Prevention, 2005
- Dietary intakes of fat and fatty acids and risk of breast cancer: A prospective study in JapanCancer Science, 2005
- No relations between breast cancer risk and fatty acids of erythrocyte membranes in postmenopausal women of the Malmö Diet Cancer cohort (Sweden)European Journal of Clinical Nutrition, 2004
- Validity and reproducibility of the food frequency questionnaire used in the Shanghai Women's Health StudyEuropean Journal of Clinical Nutrition, 2003
- Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health StudyBritish Journal of Cancer, 2003
- N‐3 and N‐6 fatty acids in breast adipose tissue and relative risk of breast cancer in a case‐control study in Tours, FranceInternational Journal of Cancer, 2001
- Polyunsaturated fatty acids in serum phospholipids and risk of breast cancer: A case-control study from the janus serum bank in NorwayEuropean Journal of Cancer, 1993