Effects of Topical Emu Oil on Burn Wounds in the Skin of Balb/c Mice
Open Access
- 1 January 2016
- journal article
- research article
- Published by Hindawi Limited in Dermatology Research and Practice
- Vol. 2016, 1-6
- https://doi.org/10.1155/2016/6419216
Abstract
The goal of this study was to determine the effect of topical Emu oil on the healing of burn wounds and hair follicle restoration in superficial II-degree burns in the skin of Balb/c mice. Thirty-two male Balb/c mice with burns on the back of the neck were divided into two groups: The Emu oil group received topical Emu oil twice daily, whereas the control was left untreated. Skin biopsies were obtained on days 4, 7, 10, and 14 of the experiment. Then the specimens were viewed with Olympus SZX research microscope. The Emu oil treated burns were found to heal more slowly and inflammation lasted longer in this group. The number of hair follicles in the margins of the wounds increased through time in the Emu oil group compared to the control group. Also, the hair follicles in the Emu oil group were in several layers and seemed to be more active and mature. Moreover, Emu oil had a positive effect on fibrogenesis and synthesis of collagen. The findings indicate that although Emu oil delays the healing process, it has a positive effect on wound healing and it increases the number of hair follicles in the margins of the wound.Keywords
Funding Information
- Birjand University of Medical Sciences (497)
This publication has 18 references indexed in Scilit:
- Emu Oil: A novel therapeutic for disorders of the gastrointestinal tract?Journal of Gastroenterology and Hepatology, 2012
- Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar ratsAnatomy & Cell Biology, 2012
- Epidemiology of burns throughout the world. Part I: Distribution and risk factorsBurns, 2011
- Effect of aloe cream versus silver sulfadiazine for healing burn wounds in rats.2010
- Safety and healing efficacy of Sea buckthorn (Hippophae rhamnoides L.) seed oil on burn wounds in ratsFood and Chemical Toxicology, 2009
- Interleukin-6 Deficiency Increases Inflammatory Bone DestructionInfection and Immunity, 2001
- B-Cell Deficiency Predisposes Mice to Disseminating Anaerobic Infections: Protection by Passive Antibody TransferInfection and Immunity, 2000
- Emu oil(s): A source of non-toxic transdermal anti-inflammatory agents in aboriginal medicineInflammopharmacology, 1998
- Anti-inflammatory activity of emu oils in ratsInflammopharmacology, 1997
- The role of interleukin‐1α in the pathogenesis of periapical bone destruction in a rat model systemOral Microbiology and Immunology, 1993