Aloe vera gel and thyroid hormone cream may improve wound healing in Wistar rats
Open Access
- 1 January 2012
- journal article
- Published by Korean Association of Anatomists in Anatomy & Cell Biology
- Vol. 45 (3), 170-177
- https://doi.org/10.5115/acb.2012.45.3.170
Abstract
Therapeutic effects of various treatment options in wound healing have been one of the most controversial issues in surgical science. The present study was carried out to examine and compare the effects of Aloe vera gel, thyroid hormone cream and silver sulfadiazine cream onsutured incisions in Wistar rats. In a randomized controlled trial, thirty-six Wistar male rats, 250 to 300 g, received surgical incisions followed by topical application of Aloe vera gel, thyroid hormone cream and silver sulfadiazine 1%. To assess the efficacy of each treatment technique, a histological approach was used to evaluate the mean number of fibroblasts, macrophages, neutrophils, blood vessel sections and thickness of the regenerating epithelium and dermis on days 4, 7 and 14. Re-epithelialization and angiogenesis were significantly improved in Aloe vera gel group compared with the other treatments while thyroid hormone cream had positive effects on day 4 (P≤0.05). Topical administration of Aloe vera gel is recommended as the treatment of choice for surgical incisions.Keywords
This publication has 33 references indexed in Scilit:
- Modality of wound closure after total knee replacement: are staples as safe as sutures? A retrospective study of 181 patientsPatient Safety in Surgery, 2011
- Management of neuropathic pain after surgical and non-surgical trauma with lidocaine 5% patches: study of 40 consecutive casesCurrent Medical Research and Opinion, 2009
- Efficacy and tolerability of a 5% lidocaine medicated plaster for the topical treatment of post-herpetic neuralgia: results of a long-term studyCurrent Medical Research and Opinion, 2009
- In vitro cytotoxity of silver: implication for clinical wound careBurns, 2004
- Thyroid Hormone Action on Skin: Diverging Effects of Topical versus Intraperitoneal AdministrationThyroid®, 2003
- Topical Triiodothyronine Stimulates Epidermal Proliferation, Dermal Thickening, and Hair Growth in Mice and RatsThyroid®, 2001
- Cutaneous Wound HealingNew England Journal of Medicine, 1999
- The Cytotoxic Effects of Commonly Used Topical Antimicrobial Agents on Human Fibroblasts and KeratinocytesJournal Of Trauma-Injury Infection and Critical Care, 1991
- In Vitro Responses of the Epidermis to TriiodothyronineJournal of Investigative Dermatology, 1978
- Effect of analogues of steroid and thyroxine hormones on wound healing in hamstersJournal of Periodontal Research, 1974