A Multicenter, Randomized, Placebo-Controlled Study Evaluating the Efficacy of a Combination of Propolis and Cranberry (Vaccinium macrocarpon) (DUAB®) in Preventing Low Urinary Tract Infection Recurrence in Women Complaining of Recurrent Cystitis
- 22 May 2019
- journal article
- research article
- Published by S. Karger AG in Urologia Internationalis
- Vol. 103 (1), 41-48
- https://doi.org/10.1159/000496695
Abstract
Objectives: The purpose of the study was to compare the efficacy of a product containing cranberry and propolis (DUAB) to placebo for reducing frequency of cystitis in women with recurrent acute cystitis. Method: A multicenter, placebo-controlled, randomized study of women aged >18 years with at least 4 episodes of cystitis in the previous 12 months was performed. The number of cystitis episodes over a 6-month follow-up was the primary end point. Results: Forty-two women were included in the cranberry + propolis group, and 43 women were in the placebo group. The mean age was 53 ± 18 years, with 6.2 ± 3.6 cystitis episodes in the previous year, with no differences between the 2 groups. The mean number of infections was lower in the propolis + cranberry group (respectively, 2.3 ± 1.8 vs. 3.1 ± 1.8). The total number of cystitis episodes in the first 3 months was lower in the propolis + cranberry group (0.7 ± 1.1 vs. 1.3 ± 1.1, p = 0.0257) after adjusting for water consumption. The mean time to onset of the first urinary tract infection (UTI) was also significantly longer in the propolis + cranberry group (69.9 ± 45.8 days vs. 43.3 ± 45.9, p = 0.0258). Tolerance to the treatments was good and comparable in both groups. Conclusions: We demonstrate for the first time that cranberry and propolis supplementation significantly reduces the incidence of UTIs during the first 3 months and delays the onset of an episode of cystitis.Keywords
This publication has 18 references indexed in Scilit:
- Virulence Potential and Genomic Mapping of the Worldwide Clone Escherichia coli ST131PLOS ONE, 2012
- Recurrent Urinary Tract Infection and Urinary Escherichia coli in Women Ingesting Cranberry Juice Daily: A Randomized Controlled TrialMayo Clinic Proceedings, 2012
- Propolis can potentialise the anti-adhesion activity of proanthocyanidins on uropathogenic Escherichia coli in the prevention of recurrent urinary tract infectionsBMC Research Notes, 2011
- Perturbation of Host Cell Cytoskeleton by Cranberry Proanthocyanidins and Their Effect on Enteric InfectionsPLOS ONE, 2011
- Cranberry Juice Fails to Prevent Recurrent Urinary Tract Infection: Results From a Randomized Placebo-Controlled TrialClinical Infectious Diseases, 2011
- Alarming β-lactamase-mediated resistance in multidrug-resistant EnterobacteriaceaeCurrent Opinion in Microbiology, 2010
- Type 1 Fimbriae, a Colonization Factor of Uropathogenic Escherichia coli, Are Controlled by the Metabolic Sensor CRP-cAMPPLoS Pathogens, 2009
- In-vitro and in-vivo evidence of dose-dependent decrease of uropathogenic Escherichia coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsulesClinical Microbiology & Infection, 2008
- Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Strains in Various Types of Private Health Care CentersAntimicrobial Agents and Chemotherapy, 2007
- Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problemMicrobes and Infection, 2003