Studies of the Antiproliferative Activity of Ruthenium (II) Cyclopentadienyl-Derived Complexes with Nitrogen Coordinated Ligands
Open Access
- 1 January 2010
- journal article
- research article
- Published by Hindawi Limited in Bioinorganic Chemistry and Applications
- Vol. 2010, 1-11
- https://doi.org/10.1155/2010/936834
Abstract
Four cationic ruthenium(II) complexes with the formula, with-phenyl-1H-tetrazole (TzH)1, imidazole (ImH)2 , benzo[1,2-b;4,3-] dithio-phen-2-carbonitrile (Bzt)3, and [5-(2-thiophen-2-yl)-vinyl]-thiophene-2-carbonitrile] (Tvt)4were prepared and characterized in view to evaluate their potentialities as antitumor agents. Studies by Circular Dichroism indicated changes in the secondary structure of ct-DNA. Changes in the tertiary structure of pBR322 plasmid DNA were also observed in gel electrophoresis experiment and the images obtained by atomic force microscopy (AFM) suggest strong interaction with pBR322 plasmid DNA; the observed decreasing of the viscosity with time indicates that the complexes do not intercalate between DNA base pairs. Compounds1,2, and3showed much higher cytotoxicity than the cisplatin against human leukaemia cancer cells (HL-60 cells).
Keywords
Funding Information
- Fundação para a Ciência e Tecnologia (PTDC/ QUI/ 66148/ 2006, SFRH/BD/12432/2003)
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