Cohort Profile: The ‘Children of the 90s’—the index offspring of the Avon Longitudinal Study of Parents and Children
Top Cited Papers
Open Access
- 16 April 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in International Journal of Epidemiology
- Vol. 42 (1), 111-127
- https://doi.org/10.1093/ije/dys064
Abstract
The Avon Longitudinal Study of Parents and Children (ALSPAC) is a transgenerational prospective observational study investigating influences on health and development across the life course. It considers multiple genetic, epigenetic, biological, psychological, social and other environmental exposures in relation to a similarly diverse range of health, social and developmental outcomes. Recruitment sought to enrol pregnant women in the Bristol area of the UK during 1990–92; this was extended to include additional children eligible using the original enrolment definition up to the age of 18 years. The children from 14 541 pregnancies were recruited in 1990–92, increasing to 15 247 pregnancies by the age of 18 years. This cohort profile describes the index children of these pregnancies. Follow-up includes 59 questionnaires (4 weeks–18 years of age) and 9 clinical assessment visits (7–17 years of age). The resource comprises a wide range of phenotypic and environmental measures in addition to biological samples, genetic (DNA on 11 343 children, genome-wide data on 8365 children, complete genome sequencing on 2000 children) and epigenetic (methylation sampling on 1000 children) information and linkage to health and administrative records. Data access is described in this article and is currently set up as a supported access resource. To date, over 700 peer-reviewed articles have been published using ALSPAC data.Keywords
This publication has 32 references indexed in Scilit:
- Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohortInternational Journal of Epidemiology, 2012
- Epigenetic Epidemiology of Common Complex Disease: Prospects for Prediction, Prevention, and TreatmentPLoS Medicine, 2010
- Traits Contributing to the Autistic SpectrumPLOS ONE, 2010
- Association of Maternal Weight Gain in Pregnancy With Offspring Obesity and Metabolic and Vascular Traits in ChildhoodCirculation, 2010
- Fat Mass Exerts a Greater Effect on Cortical Bone Mass in Girls than BoysJournal of Clinical Endocrinology & Metabolism, 2010
- Mothers' anxiety during pregnancy is associated with asthma in their childrenJournal of Allergy and Clinical Immunology, 2009
- How Does Body Fat Influence Bone Mass in Childhood? A Mendelian Randomization ApproachJournal of Bone and Mineral Research, 2009
- Bone Fragility Contributes to the Risk of Fracture in Children, Even After Moderate and Severe TraumaJournal of Bone and Mineral Research, 2008
- A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult ObesityScience, 2007
- Maternal diet in pregnancy and offspring blood pressureArchives of Disease in Childhood, 2005