The Veno-Occlusive Mechanism of the Canine Corpus Cavernosum: Angiographic and Pharmacologic Studies
- 1 December 1987
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 138 (6), 1467-1470
- https://doi.org/10.1016/s0022-5347(17)43676-7
Abstract
Studies were designed to document the normal angiography and pressure-volume characteristics of the canine corpus cavernosum, evaluate the effects of various vasoactive agents, and characterize a veno-occlusive mechanism. In fourteen dogs, baseline cavernosography demonstrated venous drainage via six to ten tributaries arising from the crura and entering the deep penile veins. Control cavernosometry during infusion of saline at 0.33 ml./sec. led to a rise in intracavernosal pressure (ICP) from 24.9 .+-. 7.9 mm. Hg to 68.4 .+-. 21.1 mm. Hg. Intracavernosal injection of a number of vasodilators, including papaverine, nitroglycerin, acetylcholine, and prostaglandin E2, raised base-line ICP significantly, caused extreme elevation of pressure during saline infusion (> 450 mm. Hg), and narrowed or obliterated the venous lumena at the site of tunica perforation, as judged angiographically. These effects could be reversed with phenoxybenzamine or norepinephrine. Our results further support the current understanding of the canine veno-occlusive mechanism.This publication has 18 references indexed in Scilit:
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