A candidate for the cystic fibrosis locus isolated by selection for methylation-free islands
- 1 April 1987
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 326 (6116), 840-845
- https://doi.org/10.1038/326840a0
Abstract
A genomic sequence close to the cystic fibrosis locus with the characteristics of an HTF island has been selectively cloned and characterized. Two markers flanking this sequence, which is conserved throughout mammalian evolution, show a very much greater disequilibrium than that found with any existing marker. A single mutational event accounts for most cases of cystic fibrosis. The sequence is expressed, and is a candidate for the cystic fibrosis gene.This publication has 31 references indexed in Scilit:
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