THE LEKSELL GAMMA KNIFE PERFEXION AND COMPARISONS WITH ITS PREDECESSORS
- 1 September 2007
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Operative Neurosurgery
- Vol. 61 (3), 130-141
- https://doi.org/10.1227/01.neu.0000289726.35330.8a
Abstract
The objective of this study is to introduce a new radiosurgical device, the Leksell Gamma Knife Perfexion (Elekta Instruments AB, Stockholm, Sweden). Design and performance characteristics are compared with previous models of the gamma knife in a clinical setting. Performance-related features in the design of the new radiosurgical system are described, and the ability to create complex shapes of isodose volumes even with a single isocenter is demonstrated. The concept of "dynamic shaping" of dose distribution is introduced as a means of decreasing the exposure to structures outside the target. Dose plans for the Leksell Gamma Knife Models B, 4C, and Perfexion have been created for target pathologies to illustrate how the software and hardware of the new radiosurgical system can increase treatment quality, decrease treatment time, and increase patient comfort. Radiation doses to critical organs in the rest of the human body are compared. The automated collimator arrangement in the Perfexion makes it possible to produce more complex treatment volumes than with previous models of the gamma knife. This results from the enhanced ability to shape isodose volumes, even for single isocenters. The collimator arrangement and the patient positioning system also allow shorter patient transit times, reducing unwanted radiation exposure during movement between isocenters. The Perfexion exceeds the capabilities of previous gamma knife models in terms of treatment efficiency, conformity, and radiation protection. These qualities enable treatment of larger target volumes, especially close to eloquent areas. Pathologies previously inaccessible in the head and neck are now treatable due to the increased volume of the radiation cavity.Keywords
This publication has 19 references indexed in Scilit:
- Stereotactic Radiosurgery as a Salvage Treatment for Recurrent Epipharyngeal CarcinomaStereotactic and Functional Neurosurgery, 2006
- Recurrent Juvenile Nasopharyngeal Angiofibroma Treated with Gamma Knife SurgeryJournal of Korean Medical Science, 2006
- In vivo Estimation of Extracranial Doses in Stereotactic Radiosurgery with the Gamma Knife and Novalis SystemsPublished by S. Karger AG ,2006
- Stereotactic Radiosurgery as a Salvage Treatment for Recurrent Skull Base Adenoid Cystic CarcinomaStereotactic and Functional Neurosurgery, 2005
- Gamma Knife Stereotactic Radiosurgical Boost for Patients Treated Primarily with Neutron Radiotherapy for Salivary Gland NeoplasmsStereotactic and Functional Neurosurgery, 2004
- Gamma knife radiosurgery for recurrent salivary gland malignancies involving the base of skullHead & Neck, 2002
- Preliminary Application of Gamma Knife in the Treatment of Nasopharyngeal CarcinomaStereotactic and Functional Neurosurgery, 1996
- Transportation Dose and Doses to Extracranial Sites during Stereotactic Radiosurgery with the Leksell Gamma KnifeStereotactic and Functional Neurosurgery, 1996
- Radiobiology of Radiosurgery for Refractory Anxiety DisordersNeurosurgery, 1995
- A new fixation device for the Leksell stereotaxic systemJournal of Neurosurgery, 1987