Matricellular Proteins in Cardiac Adaptation and Disease
Open Access
- 1 April 2012
- journal article
- review article
- Published by American Physiological Society in Physiological Reviews
- Vol. 92 (2), 635-688
- https://doi.org/10.1152/physrev.00008.2011
Abstract
The term matricellular proteins describes a family of structurally unrelated extracellular macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue architecture, but are induced following injury and modulate cell-cell and cell-matrix interactions. When released to the matrix, matricellular proteins associate with growth factors, cytokines, and other bioactive effectors and bind to cell surface receptors transducing signaling cascades. Matricellular proteins are upregulated in the injured and remodeling heart and play an important role in regulation of inflammatory, reparative, fibrotic and angiogenic pathways. Thrombospondin (TSP)-1, -2, and -4 as well as tenascin-C and -X secreted protein acidic and rich in cysteine (SPARC), osteopontin, periostin, and members of the CCN family (including CCN1 and CCN2/connective tissue growth factor) are involved in a variety of cardiac pathophysiological conditions, including myocardial infarction, cardiac hypertrophy and fibrosis, aging-associated myocardial remodeling, myocarditis, diabetic cardiomyopathy, and valvular disease. This review discusses the properties and characteristics of the matricellular proteins and presents our current knowledge on their role in cardiac adaptation and disease. Understanding the role of matricellular proteins in myocardial pathophysiology and identification of the functional domains responsible for their actions may lead to design of peptides with therapeutic potential for patients with heart disease.Keywords
This publication has 183 references indexed in Scilit:
- Integrated protein network and microarray analysis to identify potential biomarkers after myocardial infarctionFunctional & Integrative Genomics, 2010
- The role of inflammatory and fibrogenic pathways in heart failure associated with agingHeart Failure Reviews, 2010
- Periostin promotes a fibroblastic lineage pathway in atrioventricular valve progenitor cellsDevelopmental Dynamics, 2009
- Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio‐marker of fibroproliferative disease?Journal of Cell Communication and Signaling, 2009
- Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overloadHistochemistry and Cell Biology, 2008
- Functional role of periostin in development and wound repair: implications for connective tissue diseaseJournal of Cell Communication and Signaling, 2008
- Thrombospondins: from structure to therapeuticsCellular and Molecular Life Sciences, 2008
- The CCN family of genes: a perspective on CCN biology and therapeutic potentialJournal of Cell Communication and Signaling, 2007
- Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissuesJournal of Cellular Biochemistry, 2007
- Genomic expression profiling of human inflammatory cardiomyopathy (DCMi) suggests novel therapeutic targetsJournal of Molecular Medicine, 2006