Thrombospondins: from structure to therapeutics
- 12 January 2008
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 65 (5), 672-686
- https://doi.org/10.1007/s00018-007-7484-1
Abstract
Thrombospondins are large secreted, multimodular, calcium-binding glycoproteins that have complex roles in mediating cellular processes. Determination of high-resolution structures of thrombospondins has revealed unique and interesting protein motifs. Here, we review this progress and discuss implications for function. By combining structures of modules from thrombospondins and related extracellular proteins it is now possible to prepare an overall model of the structure of thrombospondin-1 and thrombospondin-2 and discern features of other thrombospondins. (Part of a multi-author Review)Keywords
This publication has 56 references indexed in Scilit:
- ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2The EMBO Journal, 2006
- Role of TSP-5/COMP in PseudoachondroplasiaThe International Journal of Biochemistry & Cell Biology, 2004
- The N-terminus of thrombospondin: the domain stands apartThe International Journal of Biochemistry & Cell Biology, 2004
- Disease-causing Mutations in Cartilage Oligomeric Matrix Protein Cause an Unstructured Ca2+ Binding DomainOnline Journal of Public Health Informatics, 2002
- Mutations in Cartilage Oligomeric Matrix Protein Causing Pseudoachondroplasia and Multiple Epiphyseal Dysplasia Affect Binding of Calcium and Collagen I, II, and IXOnline Journal of Public Health Informatics, 2001
- Cartilage Oligomeric Matrix Protein Interacts with Type IX Collagen, and Disruptions to These Interactions Identify a Pathogenetic Mechanism in a Bone Dysplasia FamilyOnline Journal of Public Health Informatics, 2001
- Physical Characterization of the Procollagen Module of Human Thrombospondin 1 Expressed in Insect CellsOnline Journal of Public Health Informatics, 2000
- A Cartilage Oligomeric Matrix Protein Mutation Associated with Pseudoachondroplasia Changes the Structural and Functional Properties of the Type 3 DomainOnline Journal of Public Health Informatics, 2000
- Expression and initial characterization of recombinant mouse thrombospondin 1 and thrombospondin 3FEBS Letters, 1996
- Interaction of human thrombospondin with types I-V collagen: direct binding and electron microscopy.The Journal of cell biology, 1987