Rifampicin Inhibition of Protein Synthesis in Mammalian Cells
- 28 April 1978
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 200 (4340), 432-434
- https://doi.org/10.1126/science.644307
Abstract
Rifampicin produces a dose-dependent decrease in protein synthesis in rat thymocytes. At concentrations up to 200 micrograms per milliliter, rifampicin does not alter rat thymic transcription. Rifampicin causes a direct inhibition of protein synthesis in rat thymic and hepatic microsomes, and in cadaveric human hepatic microsomes. Protein synthesis inhibition could explain the toxicity of rifampicin in man.Keywords
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