Somatostatinoma Syndrome
- 9 August 1979
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 301 (6), 285-292
- https://doi.org/10.1056/nejm197908093010601
Abstract
Diabetes mellitus, steatorrhea, cholelithiasis and a tumor distorting the duodenum prompted a work-up for somatostatinoma in a 52-year-old man. The responses of pancreatic B-cells but not of A-cells to nutrient stimuli were inhibited, and growth-hormone release was suppressed, suggesting somatostatin resistance in some target tissues. Plasma somatostatin-like immunoreactivity ranged from 9000 to 13,000 pg per milliliter (normal: 88±8, mean ± S.E.M.) and was distributed in four molecular forms, including free somatostatin. The primary tumor contained 5 μg of somatostatin-like immunoreactivity per milligram of wet tissue, distributed in three of the molecular forms noted in plasma. Plasma calcitonin was also elevated (4650 pg per milliliter; normal: <120). Immunocytochemical studies showed that cells of the primary tumor contained somatostatin and calcitonin but no other peptide hormones. Only somatostatin was present in the metastases. Somatostatin was localized electron microscopically in all secretory granules, irrespective of size and shape, whereas calcitonin was present only within a single subpopulation of small granules in the same cells. (N Engl J Med 301:285–292, 1979)This publication has 29 references indexed in Scilit:
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