“Somatostatinoma”: A Somatostatin-Containing Tumor of the Endocrine Pancreas
- 28 April 1977
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 296 (17), 963-967
- https://doi.org/10.1056/nejm197704282961703
Abstract
We studied the pancreatic and enteric hormone profile of a 46-year-old woman who had hyperglycemia and a pancreatic tumor. Before operation, there was no evidence of overproduction of glucagon or insulin. The tumor's ultrastructure had a distinctive endocrine morphology, resembling D cells. Prompted by the recent demonstration of somatostatin in D cells of pancreatic islets, we analyzed the tumor and found a large quantity of immunoreactive somatostatin (301 ng per milligram of tissue). Insulin, glucagon, gastrin, vasoactive intestinal polypeptide and human pancreatic polypeptide were present in only trace quantities. The tumor cells were cultured in monolayers, which remained viable up to 51 days and released somatostatin into the culture medium. In seven insulinomas and two glucagonomas, we found the somatostatin content either much lower (<0.6 ng per milligram of tissue) or undetectable.This publication has 37 references indexed in Scilit:
- Pancreatic islet cell hormones distribution of cell types in the islet and evidence for the presence of somatostatin and gastrin within the D cell.Journal of Histochemistry & Cytochemistry, 1976
- Somatostatin: Abundance of Immunoreactive Hormone in Rat Stomach and PancreasScience, 1975
- GROWTH-HORMONE RELEASE-INHIBITING HORMONE IN GASTROINTESTINAL AND PANCREATIC D CELLSThe Lancet, 1975
- Somatostatin: Hypothalamic Inhibitor of the Endocrine PancreasScience, 1974
- Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth HormoneScience, 1973
- Effects of Glucose on Beta Cells in Pancreatic Monolayer CulturesEndocrinology, 1973
- HyperparathyroidismAnnals of Surgery, 1972
- The ultrastructure of the human pancreatic isletsDiabetologia, 1971
- D Cell, the Third Endocrine Element of the Pancreatic IsletArchivum histologicum japonicum, 1968
- A sensitive double antibody radioimmunoassay for Human Growth hormone (HGH): levels of serum HGH following rapid tolbutamide infusionDiabetologia, 1967