Characterization of focal liver lesions by ADC measurements using a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging technique
- 25 October 2007
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Radiology
- Vol. 18 (3), 477-485
- https://doi.org/10.1007/s00330-007-0785-9
Abstract
The aim of this study was to determine apparent diffusion coefficients (ADCs) of focal liver lesions on the basis of a respiratory triggered diffusion-weighted single-shot echo-planar MR imaging sequence (DW-SS-EPI) and to evaluate whether ADC measurements can be used to characterize lesions. One hundred and two patients with focal liver lesions [11 hepatocellular carcinomas (HCC), 82 metastases, 4 focal nodular hyperplasias (FNH), 56 hemangiomas and 51 cysts; mean size, 16.6 mm; range 5–92 mm] were examined on a 1.5-T system using respiratory triggered DW-SS-EPI (b-values: 50, 300, 600 s/mm2). Results were correlated with histopathologic data and follow-up imaging. The ADCs of different lesion types were compared, and lesion discrimination using optimal thresholds for ADCs was evaluated. Mean ADCs (×10−3mm2/s) were 1.24 and 1.04 for normal and cirrhotic liver parenchyma and 1.05, 1.22, 1.40, 1.92 and 3.02 for HCCs, metastases, FNHs, hemangiomas and cysts, respectively. Mean ADCs differed significantly for all lesion types except for comparison of metastases with HCCs and FNHs. Overall, 88% of lesions were correctly classified as benign or malignant using a threshold value of 1.63 × 10−3mm2/s. Measurements of the ADCs of focal liver lesions on the basis of a respiratory triggered DW-SS-EPI sequence may constitute a useful supplementary method for lesion characterization.Keywords
This publication has 34 references indexed in Scilit:
- Extracranial applications of diffusion-weighted magnetic resonance imagingEuropean Radiology, 2007
- Hepatic Metastases: Diffusion-weighted Sensitivity-encoding versus SPIO-enhanced MR ImagingRadiology, 2006
- Basic principles of diffusion-weighted imagingEuropean Journal of Radiology, 2003
- Diffusion-weighted single-shot echoplanar MR imaging for liver disease.American Journal of Roentgenology, 1999
- Usefulness of diffusion-weighted MRI with echo-planar technique in the evaluation of cellularity in gliomasJournal of Magnetic Resonance Imaging, 1999
- Breath-Hold T2-Weighted MRI of Hepatic Tumors: Value of Echo Planar Imaging with Diffusion-Sensitizing GradientJournal of Computer Assisted Tomography, 1998
- Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions.American Journal of Roentgenology, 1998
- Acute and chronic stroke: navigated spin-echo diffusion-weighted MR imaging.Radiology, 1996
- Echo-planar imaging of intravoxel incoherent motion.Radiology, 1990
- Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging.Radiology, 1988