Hepatic Metastases: Diffusion-weighted Sensitivity-encoding versus SPIO-enhanced MR Imaging
- 1 April 2006
- journal article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 239 (1), 122-130
- https://doi.org/10.1148/radiol.2383041384
Abstract
Purpose: To retrospectively compare accuracy of diffusion-weighted (DW) single-shot echo-planar imaging with sensitivity encoding (SENSE) with that of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance (MR) imaging in the evaluation of hepatic metastases due to extrahepatic malignancies. Materials and Methods: Patients provided informed consent; ethics committee approval was not required. The data of 24 patients (16 men, eight women; age range, 41–68 years; mean age, 61.9 years) with 40 resected hepatic metastases were retrospectively reviewed. Before SPIO administration, DW SENSE imaging and T2-weighted fast spin-echo (SE) and T1-weighted dual-echo fast field-echo (FFE) MR imaging were performed. After SPIO administration, T2-weighted fast SE, T1-weighted dual-echo, and T2*-weighted FFE MR examinations were performed. Images were divided into two sets: The SPIO-enhanced MR image set consisted of pre- and postcontrast T2-weighted fast SE and dual-echo T1-weighted FFE images and postcontrast T2*-weighted FFE images. The DW SENSE image set included DW SENSE images and precontrast T2-weighted fast SE and dual-echo T1-weighted FFE images. Three radiologists individually interpreted these images and sorted the confidence levels for presence of hepatic metastasis in each section into five grades. Area under the receiver operating characteristic (ROC) curve (Az) was calculated for each image set. Results: Hepatic metastases showed higher signal intensity on DW SENSE images than on T2-weighted fast SE images. Conversely, signals from vessels and cysts were suppressed with DW SENSE imaging. ROC analysis showed higher Az values when the DW SENSE image set was interpreted (0.90) than when the SPIO-enhanced MR image set was interpreted (0.81). The sensitivity and specificity, respectively, of total cases were 0.66 and 0.90, for the SPIO-enhanced MR image set and 0.82 and 0.94 for the DW SENSE image set. During SPIO-enhanced MR image interpretation, lesions 1 cm in diameter or smaller showed significantly lower sensitivity than lesions larger than 1 cm in diameter. During both interpretation sessions, left lobe lesions showed significantly lower sensitivity than right lobe lesions. Conclusion: Combined reading of DW SENSE images and T2-weighted fast SE and dual-echo T1-weighted FFE MR images showed higher accuracy in the detection of hepatic metastases than did reading of SPIO-enhanced MR images. © RSNA, 2006Keywords
This publication has 25 references indexed in Scilit:
- Preoperative evaluation of malignant liver tumors: comparison of unenhanced and SPIO (Resovist)-enhanced MR imaging with biphasic CTAP and intraoperative USEuropean Radiology, 2003
- Colorectal metastasis (liver and lung)Surgical Clinics of North America, 2002
- Hepatic Resection for Metastatic Tumors From Gastric CancerAnnals of Surgery, 2002
- Simultaneous correction of ghost and geometric distortion artifacts in EPI using a multiecho reference scanIEEE Transactions on Medical Imaging, 2001
- Intraoperative Ultrasonography versus Helical Computed Tomography and Computed Tomography with Arterioportography in Diagnosing Colorectal Liver Metastases: Lesion‐by‐lesion AnalysisWorld Journal of Surgery, 2000
- Diffusion-weighted single-shot echoplanar MR imaging for liver disease.American Journal of Roentgenology, 1999
- Diffusion-weighted MR imaging with a single-shot echoplanar sequence: detection and characterization of focal hepatic lesions.American Journal of Roentgenology, 1998
- Diagnosis of liver metastases from colorectal adenocarcinomaActa Radiologica, 1997
- Detection of hepatic metastases: ferumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography.Radiology, 1996
- MRI of Liver Metastases from Colorectal Cancer vs. CT during Arterial PortographyJournal of Computer Assisted Tomography, 1993