Modeling the role of p53 pulses in DNA damage- induced cell death decision
Open Access
- 22 June 2009
- journal article
- Published by Springer Science and Business Media LLC in BMC Bioinformatics
- Vol. 10 (1), 190
- https://doi.org/10.1186/1471-2105-10-190
Abstract
The tumor suppressor p53 plays pivotal roles in tumorigenesis suppression. Although oscillations of p53 have been extensively studied, the mechanism of p53 pulses and their physiological roles in DNA damage response remain unclear.This publication has 64 references indexed in Scilit:
- Oscillations and bistability in the stochastic model of p53 regulationJournal of Theoretical Biology, 2008
- Explaining oscillations and variability in the p53-Mdm2 systemBMC Systems Biology, 2008
- Recurrent Initiation: A Mechanism for Triggering p53 Pulses in Response to DNA DamageMolecular Cell, 2008
- Two Independent Positive Feedbacks and Bistability in the Bcl-2 Apoptotic SwitchPLOS ONE, 2008
- Modeling of the Role of a Bax-Activation Switch in the Mitochondrial Apoptosis DecisionBiophysical Journal, 2007
- Emerging roles of nuclear protein phosphatasesNature Reviews Molecular Cell Biology, 2007
- Akt versus p53 in a Network of Oncogenes and Tumor Suppressor Genes Regulating Cell Survival and DeathBiophysical Journal, 2006
- Oscillations and variability in the p53 systemMolecular Systems Biology, 2006
- Intrinsic tumour suppressionNature, 2004
- DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociationNature, 2003