ACCELERATED SKIN GRAFT REJECTION IN HUMANS PRE-IMMUNIZED WITH HOMOLOGOUS PERIPHERAL LEUKOCYTES*

Abstract

The intradermal inoculation of peripheral leukocytes prior to full thickness skin grafting induced white graft and accelerated rejection of first set homografts in the human. Simultaneously placed skin grafts obtained from patients other than the leukocyte donor were also rejected in an accelerated fashion, indicating that transplantation immunity in the human is not individual specific. It is postulated that the type of skin graft rejection encountered in this experiment was determined by both the dose of immunizing leukocytes administered and the genetic similarity between donor of immunizing leukocytes and donor of the nonspecific skin graft.