Effects of exercise in people with haemophilia: An umbrella review of systematic reviews and meta‐analyses
- 30 October 2019
- journal article
- review article
- Published by Wiley in Haemophilia
- Vol. 25 (6), 928-937
- https://doi.org/10.1111/hae.13868
Abstract
Introduction There is considerable evidence to indicate that exercise can have a positive impact on the treatment of people with haemophilia (PWH). However, there is a requirement for in‐depth and comprehensive studies. Aim This study aimed to analyse the evidence regarding the effects of exercise in PWH through an umbrella review of existing systematic reviews and meta‐analyses. The secondary objective was to analyse the quality of the evidence. Methods This umbrella review followed the PRISMA guidelines and was documented in the PROSPERO registry (CRD42019140785). We searched the PubMed, Web of Science, SPORTDiscus, Scopus, CINAHL and Cochrane Library databases. The methodological quality of the systematic reviews was assessed using AMSTAR 2. Results Out of a total of 1030 systematic reviews, 10 fulfilled the criteria. Only one study was classified as high quality, and half of the selected studies were classified as low or critically low quality according to AMSTAR 2. Furthermore, most reviews investigated the effects of strength training and aquatic training, with positive results associated with low adverse events. Range of motion, strength and pain were the most investigated variables. All reviews showed overlapping studies. Conclusion Exercise is an effective way to treat haemophilia and has a low incidence of related adverse events. However, caution is needed in the interpretation of the results due to half of the selected reviews showed low or critically low quality and only one have high quality.Keywords
Funding Information
- Fundação de Amparo à Pesquisa e Inovação do Estado de Santa Catarina (PAP 04/2016)
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
This publication has 50 references indexed in Scilit:
- Physiotherapy Treatment in Patients with Hemophilia and Chronic Ankle Arthropathy: A Systematic ReviewRehabilitation Research and Practice, 2013
- Guidelines for the management of hemophiliaHaemophilia, 2012
- Psychosocial aspects of haemophilia: a systematic review of methodologies and findingsHaemophilia, 2011
- An international registry of systematic-review protocolsThe Lancet, 2011
- AMSTAR is a reliable and valid measurement tool to assess the methodological quality of systematic reviewsJournal of Clinical Epidemiology, 2009
- Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analysesCMAJ : Canadian Medical Association Journal, 2009
- Hemophilic joint disease – current perspective and potential future strategiesTransfusion and Apheresis Science, 2008
- Utilization of the PICO framework to improve searching PubMed for clinical questionsBMC Medical Informatics and Decision Making, 2007
- Bone properties and muscle strength of young haemophilia patientsHaemophilia, 2005
- Exercise and Training Effects on Blood Haemostasis in Health and DiseaseSports Medicine, 2004