The Past and Future of Tuberculosis Research
Open Access
- 26 October 2009
- journal article
- review article
- Published by Public Library of Science (PLoS) in PLoS Pathogens
- Vol. 5 (10), e1000600
- https://doi.org/10.1371/journal.ppat.1000600
Abstract
Renewed efforts in tuberculosis (TB) research have led to important new insights into the biology and epidemiology of this devastating disease. Yet, in the face of the modern epidemics of HIV/AIDS, diabetes, and multidrug resistance--all of which contribute to susceptibility to TB--global control of the disease will remain a formidable challenge for years to come. New high-throughput genomics technologies are already contributing to studies of TB's epidemiology, comparative genomics, evolution, and host-pathogen interaction. We argue here, however, that new multidisciplinary approaches--especially the integration of epidemiology with systems biology in what we call "systems epidemiology"--will be required to eliminate TBKeywords
This publication has 61 references indexed in Scilit:
- Identification of small RNAs in Mycobacterium tuberculosisMolecular Microbiology, 2009
- Genomewide Association Studies and Human DiseaseNew England Journal of Medicine, 2009
- Common Genetic Variation and Human TraitsNew England Journal of Medicine, 2009
- Drivers of tuberculosis epidemics: The role of risk factors and social determinantsSocial Science & Medicine, 2009
- A replication clock for Mycobacterium tuberculosisNature Medicine, 2009
- RNA-Seq: a revolutionary tool for transcriptomicsNature Reviews Genetics, 2009
- The clinical consequences of strain diversity in Mycobacterium tuberculosisTransactions of the Royal Society of Tropical Medicine and Hygiene, 2008
- Progression to Active Tuberculosis, but Not Transmission, Varies byMycobacterium tuberculosisLineage in The GambiaThe Journal of Infectious Diseases, 2008
- Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope DatabaseTuberculosis, 2008
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998