Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
- 11 June 1998
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 393 (6685), 537-544
- https://doi.org/10.1038/31159
Abstract
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.Keywords
This publication has 36 references indexed in Scilit:
- Inhibition of a Mycobacterium tuberculosis β-Ketoacyl ACP Synthase by IsoniazidScience, 1998
- The Complete Genome Sequence of Escherichia coli K-12Science, 1997
- tRNAscan-SE: A Program for Improved Detection of Transfer RNA Genes in Genomic SequenceNucleic Acids Research, 1997
- Components of Eukaryotic-like Protein Signaling Pathways inMycobacterium tuberculosisMicrobial & Comparative Genomics, 1997
- In search of tuberculosis virulence genesTrends in Microbiology, 1996
- Inhibition of antigen processing by the internal repeat region of the Epstein–Barr virus nuclear antigen-1Nature, 1995
- Bacterial genomicsFEMS Microbiology Reviews, 1994
- Cloning of an M. tuberculosis DNA fragment associated with entry and survival inside cellsScience, 1993
- Genetic variation in pathogenic bacteriaTrends in Genetics, 1992
- Basic local alignment search toolJournal of Molecular Biology, 1990