Development and validation of PRE-DELIRIC (PREdiction of DELIRium in ICu patients) delirium prediction model for intensive care patients: observational multicentre study
Top Cited Papers
Open Access
- 9 February 2012
- Vol. 344 (feb09 3), e420
- https://doi.org/10.1136/bmj.e420
Abstract
To develop and validate a delirium prediction model for adult intensive care patients and determine its additional value compared with prediction by caregivers. Observational multicentre study. Five intensive care units in the Netherlands (two university hospitals and three university affiliated teaching hospitals). 3056 intensive care patients aged 18 years or over. Development of delirium (defined as at least one positive delirium screening) during patients' stay in intensive care. The model was developed using 1613 consecutive intensive care patients in one hospital and temporally validated using 549 patients from the same hospital. For external validation, data were collected from 894 patients in four other hospitals. The prediction (PRE-DELIRIC) model contains 10 risk factors-age, APACHE-II score, admission group, coma, infection, metabolic acidosis, use of sedatives and morphine, urea concentration, and urgent admission. The model had an area under the receiver operating characteristics curve of 0.87 (95% confidence interval 0.85 to 0.89) and 0.86 after bootstrapping. Temporal validation and external validation resulted in areas under the curve of 0.89 (0.86 to 0.92) and 0.84 (0.82 to 0.87). The pooled area under the receiver operating characteristics curve (n=3056) was 0.85 (0.84 to 0.87). The area under the curve for nurses' and physicians' predictions (n=124) was significantly lower at 0.59 (0.49 to 0.70) for both. The PRE-DELIRIC model for intensive care patients consists of 10 risk factors that are readily available within 24 hours after intensive care admission and has a high predictive value. Clinical prediction by nurses and physicians performed significantly worse. The model allows for early prediction of delirium and initiation of preventive measures. Trial registration Clinical trials NCT00604773 (development study) and NCT00961389 (validation study).This publication has 27 references indexed in Scilit:
- Different assessment tools for intensive care unit delirium: Which score to use?*Critical Care Medicine, 2010
- The Delirium Observation Screening Scale Recognizes Delirium Early after Cardiac SurgeryEuropean Journal of Cardiovascular Nursing, 2009
- Comparison of delirium assessment tools in a mixed intensive care unit*Critical Care Medicine, 2009
- Occurrence of delirium is severely underestimated in the ICU during daily careIntensive Care Medicine, 2009
- Implementation of a delirium assessment tool in the ICU can influence haloperidol useCritical Care, 2009
- Incidence, risk factors and consequences of ICU deliriumIntensive Care Medicine, 2006
- Costs associated with delirium in mechanically ventilated patients*Critical Care Medicine, 2004
- The impact of delirium in the intensive care unit on hospital length of stayIntensive Care Medicine, 2001
- Delirium in an intensive care unit: a study of risk factorsIntensive Care Medicine, 2001
- A Multicomponent Intervention to Prevent Delirium in Hospitalized Older PatientsThe New England Journal of Medicine, 1999