Long-term accumulation of uranium in bones of Wistar rats as a function of intake dosages
- 5 October 2004
- journal article
- research article
- Published by Oxford University Press (OUP) in Radiation Protection Dosimetry
- Vol. 112 (3), 385-393
- https://doi.org/10.1093/rpd/nch405
Abstract
Groups of Wistar rats were fed with ration doped with uranyl nitrate at concentration A ranging from 0.5 to 100 ppm, starting after the weaning period and lasting until the postpuberty period when the animals were sacrificed. Uranium in the ashes of bones was determined by neutron activation analysis. It was found that the uranium concentration in the bones, as a function of A, exhibits a change in its slope at ∼20 ppm—a probable consequence of the malfunctioning of kidneys. The uranium transfer coefficient was obtained and an analytical expression was fitted into the data, thus allowing extrapolation down to low doses. Internal and localized doses were calculated. Absorbed doses exceeded the critical dose, even for the lowest uranium dosage.Keywords
This publication has 16 references indexed in Scilit:
- Long‐term accumulation and microdistribution of uranium in the bone and marrow of beagle dogInternational Journal of Radiation Biology, 2004
- Reproductive and developmental toxicity of natural and depleted uranium: a reviewReproductive Toxicology, 2001
- A Biokinetic Model for Alpha-emitting Bone Surface-seeking Radionuclides in the Mouse SkeletonRadiation Protection Dosimetry, 2000
- Microdosimetry to Leukaemogenic Target Cells for Bone-Incorporated Alpha-Emitting RadionuclidesRadiation Protection Dosimetry, 1998
- A review of radiologically important trace elements in human bones.Applied Radiation and Isotopes, 1998
- Chronic Ingestion of Uranium in Drinking Water: A Study of Kidney Bioeffects in HumansToxicological Sciences, 1998
- Concentrations of uranium in animal feed supplements: Measurements and dose estimatesJournal of Radioanalytical and Nuclear Chemistry, 1997
- A sensitive method for the determination of uranium in biological samples utilizing kinetic phosphorescence analysis (KPA)Journal of Pharmaceutical and Biomedical Analysis, 1997
- The architecture of bone marrow cell populationsThe International Journal of Cell Cloning, 1990
- Absorption of Actinide Elements From the Gastrointestinal Tract of Rats, Guinea Pigs and DogsHealth Physics, 1980