Highly bioactive zeolitic imidazolate framework-8-capped nanotherapeutics for efficient reversal of reperfusion-induced injury in ischemic stroke
Top Cited Papers
Open Access
- 1 March 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 6 (12), eaay9751
- https://doi.org/10.1126/sciadv.aay9751
Abstract
Rational design of potent antioxidative agent with high biocompatibility is urgently needed to treat ischemic reperfusion-induced ROS-mediated cerebrovascular and neural injury during ischemia strokes. Here, we demonstrate an in situ synthetic strategy of bioactive zeolitic imidazolate framework-8-capped ceria nanoparticles (CeO2@ZIF- 8 NPs) to achieve enhanced catalytic and antioxidative activities and improved stroke therapeutic efficacy. This nanosystem exhibits prolonged blood circulation time, reduced clearance rate, improved BBB penetration ability, and enhanced brain accumulation, where it effectively inhibits the lipid peroxidation in brain tissues in middle cerebral artery occlusion mice and reduces the oxidative damage and apoptosis of neurons in brain tissue. CeO2@ZIF-8 also suppresses inflammation- and immune response-induced injury by suppressing the activation of astrocytes and secretion of proinflammatory cytokines, thus achieving satisfactory prevention and treatment in neuroprotective therapy. This study also sheds light on the neuroprotective action mechanisms of ZIF-8-capped nanomedicine against reperfusion-induced injury in ischemic stroke.Funding Information
- National Natural Science Foundation of China (21877049)
This publication has 39 references indexed in Scilit:
- StrokeThe Lancet, 2016
- Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammationThe Lancet Neurology, 2016
- One-pot Synthesis of Metal–Organic Frameworks with Encapsulated Target Molecules and Their Applications for Controlled Drug DeliveryJournal of the American Chemical Society, 2016
- Immune interventions in strokeNature Reviews Neurology, 2015
- Cerium oxide nanoparticle: a remarkably versatile rare earth nanomaterial for biological applicationsNPG Asia Materials, 2014
- Ceria Nanoparticles that can Protect against Ischemic StrokeAngewandte Chemie-International Edition, 2012
- The reversal of cisplatin-induced nephrotoxicity by selenium nanoparticles functionalized with 11-mercapto-1-undecanol by inhibition of ROS-mediated apoptosisBiomaterials, 2011
- Oxidative Stress and Its Role in the Pathogenesis of Ischaemic StrokeInternational Journal of Stroke, 2009
- In Vitro Antioxidant and Antiproliferative Activities of Selenium-Containing Phycocyanin from Selenium-EnrichedSpirulina platensisJournal of Agricultural and Food Chemistry, 2008
- Secondary Prevention of Recurrent StrokeStroke, 2005