Water- and nutrient-dependent effects of dietary restriction on Drosophila lifespan
- 3 November 2009
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 106 (44), 18633-18637
- https://doi.org/10.1073/pnas.0908016106
Abstract
Dietary restriction (DR) is a widely conserved intervention leading to lifespan extension. Despite considerable effort, the mechanisms underlying DR remain poorly understood. In particular, it remains unclear whether DR prolongs life through conserved mechanisms in different species. Here, we show that, in the most common experimental conditions, lifespan extension by DR is abolished by providing Drosophila with ad libitum water, without altering food intake, indicating that DR, as conventionally studied in flies, is fundamentally different from the phenomenon studied in mammals. We characterize an alternative dietary paradigm that elicits robust lifespan extension irrespective of water availability, and thus likely represents a more relevant model for mammalian DR. Our results support the view that protein:carbohydrate ratio is the main dietary determinant of fly lifespan. These findings have broad implications for the study of lifespan and nutrition.Keywords
This publication has 39 references indexed in Scilit:
- Caloric Restriction Delays Disease Onset and Mortality in Rhesus MonkeysScience, 2009
- Longevity–fertility trade‐offs in the tephritid fruit fly,Anastrepha ludens, across dietary‐restriction gradientsAging Cell, 2008
- Lifespan and reproduction in Drosophila : New insights from nutritional geometryProceedings of the National Academy of Sciences of the United States of America, 2008
- Prandiology of Drosophila and the CAFE assayProceedings of the National Academy of Sciences of the United States of America, 2007
- Dietary Restriction in Drosophila: Delayed Aging or Experimental Artefact?PLoS Genetics, 2007
- Counting calories in Drosophila diet restrictionExperimental Gerontology, 2007
- Allocrine Modulation of Feeding Behavior by the Sex Peptide of DrosophilaCurrent Biology, 2006
- Calories Do Not Explain Extension of Life Span by Dietary Restriction in DrosophilaPLoS Biology, 2005
- Sirtuin activators mimic caloric restriction and delay ageing in metazoansNature, 2004
- Linear relationship between lethal mutation yield and intake of ethyl methanesulfonate in Drosophila melanogasterEnvironmental Mutagenesis, 1985