Sirtuin activators mimic caloric restriction and delay ageing in metazoans
Top Cited Papers
- 14 July 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 430 (7000), 686-689
- https://doi.org/10.1038/nature02789
Abstract
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases2,3. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast4. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction.Keywords
This publication has 22 references indexed in Scilit:
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003
- Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant fliesProceedings of the National Academy of Sciences of the United States of America, 2003
- Genetics and the Specificity of the Aging ProcessScience, 2003
- How does calorie restriction work?Journal of Bone and Joint Surgery, 2003
- Longevity Regulation by Drosophila Rpd3 Deacetylase and Caloric RestrictionScience, 2002
- Requirement of NAD and SIR2 for Life-Span Extension by Calorie Restriction in Saccharomyces cerevisiaeScience, 2000
- An intervention resembling caloric restriction prolongs life span and retards aging in yeastThe FASEB Journal, 2000
- Resveratrol: A molecule whose time has come? And gone?Clinical Biochemistry, 1997
- Female fitness inDrosophila melanogaster: an interaction between the effect of nutrition and of encounter rate with malesProceedings. Biological sciences, 1996
- Phenotypic plasticity and selection in Drosophila life‐history evolution. I. Nutrition and the cost of reproductionJournal of Evolutionary Biology, 1993