Efficient stabilization of natural curcuminoids mediated by oil body encapsulation
- 1 March 2013
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in RSC Advances
- Vol. 3 (16), 5422-5429
- https://doi.org/10.1039/c3ra40552d
Abstract
Curcumin is a natural hydrophobic polyphenol found in the powdered rhizomes of Curcuma longa. Due to its capacity to interfere with many signalling pathways, it has been shown that curcumin has potential beneficial pharmacological effects including antioxidant, anti-inflammatory, anticarcinogenic properties. However, the use of curcumin is fairly restricted because of its poor water solubility, low bioavailability, inadequate tissue absorption and degradation at alkaline pH. In the present contribution, we first verified the anti-proliferative effects of natural curcuminoids towards two different cell lines derived from an ovarian and a breast adenocarcinoma cancer. Later, curcuminoids were successfully encapsulated into reconstituted oil bodies. Once encapsulated into the triacylglycerol cores of the reconstituted oil bodies, curcumin, the most hydrophobic and active of the three curcuminoids, was better stabilized in comparison with albumin stabilization. Oil body encapsulated curcuminoids showed the same effects on cancer cell viability as the free drug, confirming the great potential of natural oil bodies as micro/nano-capsules in drug delivery applications.Keywords
This publication has 34 references indexed in Scilit:
- Natural substances and Alzheimer's disease: From preclinical studies to evidence based medicineBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
- Investigation of the Absorption Mechanism of Solubilized Curcumin Using Caco-2 Cell MonolayersJournal of Agricultural and Food Chemistry, 2011
- Curcumin improves MMC-based chemotherapy by simultaneously sensitising cancer cells to MMC and reducing MMC-associated side-effectsEuropean Journal of Cancer, 2011
- Bioavailability of Curcumin: Problems and PromisesMolecular Pharmaceutics, 2007
- Nuclear factor-κB: The enemy withinCancer Cell, 2004
- Induction of apoptosis in human lung cancer cells by curcuminCancer Letters, 2004
- Biological Properties of Curcumin-Cellular and Molecular Mechanisms of ActionCritical Reviews in Food Science and Nutrition, 2004
- Curcuma longa Extract Supplementation Reduces Oxidative Stress and Attenuates Aortic Fatty Streak Development in RabbitsArteriosclerosis, Thrombosis, and Vascular Biology, 2002
- Inhibition of human low density lipoprotein oxidation by active principles from spicesMolecular and Cellular Biochemistry, 2002
- Integrity of erythrocytes of hypercholesterolemic rats during spices treatmentMolecular and Cellular Biochemistry, 2002