Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies.
- 1 August 1994
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 90 (2), 769-774
- https://doi.org/10.1161/01.cir.90.2.769
Abstract
BACKGROUND The relative importance of HDL2 and HDL3 cholesterol as risk factors for ischemic heart disease (IHD) is still uncertain. Their associations with the incidence of IHD in the Caerphilly and Speedwell prospective studies are described. METHODS AND RESULTS The two studies have a common core protocol and are based on a total of 4860 middle-aged men from the general population. The first follow-up was at a nearly constant interval of 5.1 years in Caerphilly and 3.2 years in Speedwell: 251 major IHD events had occurred. Lipid levels were measured on fasting samples. Different laboratories were used by the two studies. Each laboratory used ultracentrifugation to separate HDL2 and HDL3. Both subfractions were inversely associated with risk of IHD. Standardized relative odds of developing major IHD were 0.95 (95% confidence interval [CI], 0.80 to 1.14) for HDL2 cholesterol and 0.83 (95% CI, 0.68 to 1.00) for HDL3 cholesterol in Caerphilly and 0.76 (95% CI, 0.57 to 1.01) for HDL2 and 0.64 (95% CI, 0.49 to 0.83) for HDL3 in Speedwell. The association with incident IHD appeared to be stronger for HDL3 in both areas. No linear combination of the two subfractions was a better predictor of IHD than total HDL cholesterol alone. CONCLUSIONS In British men, both HDL2 and HDL3 cholesterol are inversely associated with the incidence of IHD. However, the prediction of the risk of IHD from total HDL cholesterol alone could not be improved upon by measurement of the two HDL subfractions. The relative value of the two HDL subfractions as predictors of risk is still unresolved. The uncertainty may be due, at least in part, to problems associated with their measurement.Keywords
This publication has 15 references indexed in Scilit:
- Plasma triglyceride and high density lipoprotein cholesterol as predictors of ischaemic heart disease in British men: The Caerphilly and Speedwell Collaborative Heart Disease StudiesHeart, 1992
- Bias in relative odds estimation owing to imprecise measurement of correlated exposuresStatistics in Medicine, 1992
- A Prospective Study of Cholesterol, Apolipoproteins, and the Risk of Myocardial InfarctionNew England Journal of Medicine, 1991
- How independent are “independent” effects? relative risk estimation when correlated exposures are measured impreciselyJournal of Clinical Epidemiology, 1991
- Concentrations of high density lipoprotein cholesterol, triglycerides, and total cholesterol in ischaemic heart disease.BMJ, 1989
- Associations of alcohol consumption with plasma high density lipoprotein cholesterol and its major subfractions: the Caerphilly and Speedwell Collaborative Heart Disease Studies.Journal of Epidemiology and Community Health, 1988
- Associations of high-density lipoprotein subclasses and apolipoproteins with ischemic heart disease and coronary atherosclerosisAmerican Heart Journal, 1987
- STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENTThe Lancet, 1986
- A micro-method for the rapid ultracentrifugal separation of human plasma high density lipoprotein subfractions, HDL2 and HDL3Clinica Chimica Acta; International Journal of Clinical Chemistry, 1981
- Ischemic Heart Disease, Atherosclerosis, and LongevityCirculation, 1966