Lethal Pulmonary Reactions Associated with the Combined Use of Amphotericin B and Leukocyte Transfusions
- 14 May 1981
- journal article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 304 (20), 1185-1189
- https://doi.org/10.1056/nejm198105143042001
Abstract
Amphotericin B is used increasingly in high-risk patients with profound neutropenia and suspected sepsis. We have observed serious pulmonary reactions characterized by acute dyspnea, hypoxemia, and interstitial infiltrates on chest films in patients receiving amphotericin B and leukocyte transfusions. We reviewed 6 1/2 years of experience at the National Institutes of Health to determine whether this combination was associated with pulmonary toxicity not characteristic of either therapy alone.Keywords
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