Successful Granulocyte Transfusion Therapy for Gram-Negative Septicemia
- 31 March 1977
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 296 (13), 701-705
- https://doi.org/10.1056/nejm197703312961301
Abstract
We prospectively randomized 27 granulocytopenic patients who experienced a total of 30 episodes of gram-negative septicemia. The control group received an appropriate antibiotic regimen alone, whereas the "transfusion" group received infusions of granulocytes in addition to the antibiotics. Five of 14 controls survived, and 12 of 16 in the transfusion group survived (P<0.04). An important factor in the outcome of treatment was the recovery of bone-marrow function (return of peripheral granulocyte count ≥1000 per microliter). Eighty-three per cent (five of six) of the control group and all (four of four) of the transfusion group with recovery of granulocyte levels survived the episode of sepsis. In contrast, none of the eight control patients, as compared to 67 per cent (eight of 12) of the transfusion group, survived persistent granulocytopenia (P<0.005). Granulocyte transfusions appear to complement appropriate antibiotic treatment of gram-negative-septicemia due to granulocytopenia. (N Engl J Med 296:701–705, 1977)This publication has 2 references indexed in Scilit:
- Quantitative Relationships Between Circulating Leukocytes and Infection in Patients with Acute LeukemiaAnnals of Internal Medicine, 1966
- Agranulocytosis: Its Classification*†Annals of Internal Medicine, 1931