Diffusion-Weighted Magnetic Resonance Imaging of Uterine Cervical Cancer
- 1 November 2009
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Computer Assisted Tomography
- Vol. 33 (6), 858-862
- https://doi.org/10.1097/rct.0b013e31819e93af
Abstract
To determine the feasibility of diffusion-weighted magnetic resonance (MR) imaging (DWI) of uterine cervical cancer and to investigate whether the apparent diffusion coefficient (ADC) values of cervical cancer differ from those of normal cervix and whether they could indicate the histologic type and the pathologic grade of tumor. Forty-two female patients with histopathologically proven uterine cervical cancer and 15 female patients with uterine leiomyomas underwent preoperative MR examinations using a 1.5-T clinical scanner (GE 1.5T Twin-Speed Infinity with Excite II scanner; GE Healthcare, Waukesha, Wis). Scanning sequences included T2-weighted fast spin-echo imaging, T2-weighted fast spin-echo with fat suppression imaging, T1-weighted spin-echo imaging, and DWI with diffusion factors of 0 and 1000 s/mm2. Parameters evaluated consisted of ADC values of uterine cervical cancer and normal cervix. Histologic specimens were stained with hematoxylin and eosin. The cellular densities of 32 uterine cervical cancers were calculated, which were regarded as the ratio of the total area of tumor cell nuclei divided by the area of sample image. Apparent diffusion coefficient value was statistically different (P = 0.000) between normal and cancerous tissue in the uterine cervix; the former one was (mean [SD], 1.50 [0.16]) x 10(-3) mm2/s, and the latter one was (0.88 [0.15]) x 10(-3) mm2/s. Apparent diffusion coefficient value of squamous carcinoma was statistically lower than that of adenocarcinoma (P = 0.040). The ADC value of uterine cervical cancer correlated negatively with cellular density (r = -0.711, P = 0.000) and the grading of tumor (r = -0.778, P = 0.000). Diffusion-weighted MR imaging has a potential ability to differentiate between normal and cancerous tissue in the uterine cervix, and it can indicate the histologic type of uterine cervical cancer as well. The ADC value of uterine cervical cancer represents tumor cellular density, thus providing a new method for evaluating the pathologic grading of tumor.Keywords
This publication has 19 references indexed in Scilit:
- Feasibility of diffusion‐weighted imaging in the differentiation of metastatic from nonmetastatic lymph nodes: Early experienceJournal of Magnetic Resonance Imaging, 2008
- MR Imaging: Brief Overview and Emerging ApplicationsRadioGraphics, 2007
- Lung Carcinoma: Diffusion-weighted MR Imaging—Preliminary Evaluation with Apparent Diffusion CoefficientRadiology, 2007
- The performance of magnetic resonance imaging in early cervical carcinoma: a long-term experienceInternational Journal of Gynecologic Cancer, 2007
- Extracranial applications of diffusion-weighted magnetic resonance imagingEuropean Radiology, 2007
- Diffusion-weighted MR imaging for urinary bladder carcinoma: initial resultsEuropean Radiology, 2006
- Cervical cancer: MR imaging findings before, during, and after radiation therapyEuropean Radiology, 2005
- Diagnosis, Staging, and Surveillance of Cervical CarcinomaAmerican Journal of Roentgenology, 2003
- ADC mapping by means of a single-shot spiral MRI technique with application in acute cerebral ischemiaMagnetic Resonance in Medicine, 1999
- CT and MRI of strokeJournal of Magnetic Resonance Imaging, 1996