A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue
Open Access
- 29 January 2007
- journal article
- research article
- Published by Elsevier BV in Laboratory Investigation
- Vol. 87 (4), 392-397
- https://doi.org/10.1038/labinvest.3700520
Abstract
No abstract availableThis publication has 21 references indexed in Scilit:
- Precision and Performance Characteristics of Bisulfite Conversion and Real-Time PCR (MethyLight) for Quantitative DNA Methylation AnalysisThe Journal of Molecular Diagnostics, 2006
- Prognostic Significance of O6-Methylguanine-DNA Methyltransferase Determined by Promoter Hypermethylation and Immunohistochemical Expression in Anaplastic GliomasClinical Cancer Research, 2005
- Frequent promoter hypermethylation and low expression of the MGMT gene in oligodendroglial tumorsInternational Journal of Cancer, 2004
- MGMT: its role in cancer aetiology and cancer therapeuticsNature Reviews Cancer, 2004
- Clinical Trial Substantiates the Predictive Value of O-6-Methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastoma Patients Treated with TemozolomideClinical Cancer Research, 2004
- Generating mutations but providing chemosensitivity: the role of O6-methylguanine DNA methyltransferase in human cancerOncogene, 2004
- Gene Silencing in Cancer in Association with Promoter HypermethylationThe New England Journal of Medicine, 2003
- O6‐methylguanine‐DNA methyltranspherase gene expression in gliomas by means of real‐time quantitative RT‐PCR and clinical response to nitrosoureasInternational Journal of Cancer, 2002
- Inactivation of the DNA-Repair GeneMGMTand the Clinical Response of Gliomas to Alkylating AgentsThe New England Journal of Medicine, 2000
- Aberrant CpG-island methylation has non-random and tumour-type–specific patternsNature Genetics, 2000