Gene Silencing in Cancer in Association with Promoter Hypermethylation
- 20 November 2003
- journal article
- review article
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 349 (21), 2042-2054
- https://doi.org/10.1056/nejmra023075
Abstract
This article reviews the mechanisms of gene silencing in cancer and clinical applications of this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key event in the development of cancer. The silencing can be effected by a disabling mutation or by a shutting down of the promoter region, the site at which transcription of the gene begins.Keywords
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