Excitatory effect of propiverine hydrochloride on urethral activity in rats
Open Access
- 29 February 2012
- journal article
- Published by Wiley in International Journal of Urology
- Vol. 19 (6), 575-582
- https://doi.org/10.1111/j.1442-2042.2012.02977.x
Abstract
Objectives: To investigate the effects of the antimuscarinic agent, propiverine, on the bladder and urethra in rats. Methods: A total of 54 female rats were given propiverine, imidafenacin (an antimuscarinic agent), or distilled water by gavage once or twice daily. After 2 weeks, bladder and urethral activity were recorded under urethane anesthesia. In the propiverine group, the changes of bladder and urethral activity before and after intravenous injection of α1-adrenergic antagonists (prazosin, silodosin and naftopidil) were also recorded. Furthermore, the leak point pressure after electrical stimulation of abdominal wall muscles was measured in rats with vaginal distension from the control and propiverine groups. Results: Intravesical baseline pressure was significantly lower in the propiverine and imidafenacin groups compared with the control group, whereas the urethral baseline pressure was significantly higher in the propiverine group compared with the control or imidafenacin groups. Intravenous injection of prazosin (an α1-receptor antagonist) significantly decreased the urethral baseline pressure in both of the propiverine and control groups. Intravenous injection of silodosin and naftopidil (α1A- and α1D-receptor antagonists, respectively) significantly decreased the maximum contraction pressure and the urethral baseline pressure in the propiverine group. The leak point pressure of the propiverine group was significantly higher than that of the control group. Conclusions: An increase of catecholamines after propiverine administration might activate smooth muscle of the proximal urethra via α1A- and α1D-adrenergic receptors, as well as activating urethral and pelvic floor striated muscle via the spinal motoneurons.Keywords
This publication has 25 references indexed in Scilit:
- Randomized Controlled Trial to Treat Benign Prostatic Hyperplasia with Overactive Bladder Using an Alpha‐blocker Combined with AnticholinergicsLUTS: Lower Urinary Tract Symptoms, 2010
- Catecholamines Relax Detrusor through β2-Adrenoceptors in Mouse and β3-Adrenoceptors in ManThe Journal of pharmacology and experimental therapeutics, 2008
- Involvement of reflex urethral closure mechanisms in urethral resistance under momentary stress condition induced by electrical stimulation of rat abdomenAmerican Journal of Physiology-Renal Physiology, 2007
- Pharmacology of α1-adrenoceptor antagonists in the lower urinary tract and central nervous systemNature Reviews Endocrinology, 2007
- Role of noradrenergic pathways in sneeze-induced urethral continence reflex in ratsAmerican Journal of Physiology-Renal Physiology, 2007
- Functional Analysis of Active Urethral Closure Mechanisms Under Sneeze Induced Stress Condition in a Rat Model of Birth TraumaJournal of Urology, 2006
- Efficacy and Cardiac Safety of Propiverine in Elderly Patients – A Double–Blind, Placebo–Controlled Clinical StudyEuropean Urology, 2000
- Functional and molecular biological evidence for a possible β3‐adrenoceptor in the human detrusor muscleBritish Journal of Pharmacology, 1999
- Naftopidil, a Novel α1-Adrenoceptor Antagonist, Displays Selective Inhibition of Canine Prostatic Pressure and High Affinity Binding to Cloned Human α1-AdrenoceptorsThe Japanese Journal of Pharmacology, 1999
- Serotoninergic, noradrenergic, and peptidergic innervation of Onuf's nucleus of normal and transected spinal cords of baboons (papio papio)Journal of Comparative Neurology, 1992