Functional Analysis of Active Urethral Closure Mechanisms Under Sneeze Induced Stress Condition in a Rat Model of Birth Trauma
- 31 December 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of Urology
- Vol. 176 (6), 2711-2715
- https://doi.org/10.1016/j.juro.2006.07.139
Abstract
Purpose: We evaluated changes in the urethral closure mechanism under a sneeze induced stress condition in a rat model of birth trauma. Materials and Methods: Four days after vaginal distention induced by balloon catheter inflation in the vagina sneezing was induced while recording intravesical pressure with the rat under urethane anesthesia to evaluate sneeze induced leak point pressure, defined as the lowest pressure inducing fluid leakage from the urethral meatus during sneezing. Sneeze induced responses in the bladder and proximal or mid urethra were also measured using microtip transducer catheters. Results: In 5 sham operated rats no leakage was observed from the urethral meatus during sneezing, which produced an increase in intravesical pressure of up to 34 cm H2O. However, in 5 of 6 rats with vaginal distention leakage during sneezing was observed with a sneeze leak point pressure of 26.2 cm H2O. In the mid urethra microtip transducer catheters revealed that pressure increases during sneezing were greater than those in the bladder but they were significantly decreased in the 5 incontinent vaginal distention rats. However, sneeze induced responses at the proximal urethra, which were similar to those in the bladder, were not different in sham operated and incontinent vaginal distention rats. Conclusions: Sneeze induced stress urinary incontinence in a rat model of birth trauma was caused by decreased active closure mechanisms at the mid urethra without affecting the passive transmission of abdominal pressure in the proximal urethra.Keywords
This publication has 16 references indexed in Scilit:
- Recent advances in the neurophysiology of stress urinary incontinenceScandinavian Journal of Urology and Nephrology, 2005
- Urethral closure mechanisms under sneeze-induced stress condition in rats: a new animal model for evaluation of stress urinary incontinenceAmerican Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2003
- Effects of vaginal distension on urethral anatomy and functionBJU International, 2002
- THE EFFECT OF SIMULATED BIRTH TRAUMA AND/OR OVARIECTOMY ON RODENT CONTINENCE MECHANISM. PART I: FUNCTIONAL AND STRUCTURAL CHANGEJournal of Urology, 2001
- THE COEXISTENCE OF INTRINSIC SPHINCTER DEFICIENCY WITH TYPE II STRESS INCONTINENCEJournal of Urology, 1999
- Effect of simulated birth trauma on the urinary continence mechanism in the ratUrology, 1998
- The in vivo and in vitro effects of hypoxia on pig urethral smooth muscle.BJU International, 1997
- Initial Urethral Pressure Increase during Stress Episodes in Genuine Stress Incontinent WomenBritish Journal of Urology, 1992
- Pelvic Floor Stress Response: Reflex Contraction with Pressure Transmission to the UrethraUrologia Internationalis, 1987
- Time Separation between Cough Pulses in Bladder, Rectum and Urethra in WomenJournal of Urology, 1984