Regression Analysis Between Heart Rate Variability and Baroreflex‐Related Vagus Nerve Activity in Rats
- 12 April 2005
- journal article
- Published by Wiley in Journal of Cardiovascular Electrophysiology
- Vol. 16 (8), 864-869
- https://doi.org/10.1111/j.1540-8167.2005.40656.x
Abstract
Many previous studies have suggested that the high-frequency (HF) power of the heart rate variability may represent cardiac vagal activity although direct evidence of a correlation between the HF and vagal neuronal activity is still lacking. In the present study, we performed a regression analysis of the HF and vagal neurograms. Experiments were carried out on adult male Sprague-Dawley rats anesthetized with a continuous infusion of pentobarbital sodium. The baroreflex-related vagus neuronal activities were obtained by nerve or single-fiber recordings. The transient baroreflex response was employed to alter vagus neuronal activities using a bolus injection of phenylephrine (PE). On-line power spectral analysis of the heart rate and a vagal neurogram was performed during the acute baroreflex response. During the test period, systemic arterial pressure immediately increased in response to the PE injection, after which the R-R interval (RR), HF (0.6-2.4 Hz), and vagus nerve and unit activities all dramatically increased. Both nerve and unit activities exhibited good correlations (r > or = 0.7 in all nerve recordings and r > or = 0.6 in 91% of single-fiber recordings) with the HF. There were insignificant differences between the right- and left-side baroreflex-related vagus nerve recordings. Our present study provides a direct linkage between the HF and vagus neuronal electrical activity in anesthetized rats.Keywords
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