The acute effects of oral (‐)‐tryptophan in human subjects.
- 1 April 1975
- journal article
- clinical trial
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 2 (2), 165-172
- https://doi.org/10.1111/j.1365-2125.1975.tb01572.x
Abstract
1 The psychotropic effects of a single oral dose of (--)-tryptophan (5 g) in human volunteers were investigated using a series of physiological and psychological tests. 2 Self-ratings of mood showed increase in drowsiness but no euphoria was detected. 3 Severe initial nausea occurred and headache increased; other bodily symptoms were unaffected. 4 Trptophan caused increased activity in the slow wavebands of the EEG but did not alter the other physiological measures. 5 The levels of total and free tryptophan in the plasma increased 8 and 20 fold respectively to peak levels 2 h after ingestion.This publication has 41 references indexed in Scilit:
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